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Building applications by selecting and
2020-09-01
Building applications by selecting and integrating components is known in software engineering as COTS-based development. Nowadays, this approach is recognized as a crucial success factor for the software industry (Ahuja, 2014). The advantages of using COTS components include minimizing the overall
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Additionally in the presented study both
2020-09-01
Additionally, in the presented study both the NSE values and MFI levels of the CD45−CD34 + CXCR7+ Barasertib correlated positively with the inflammatory parameter – CRP. CXCR7 expression has been found to be enhanced during pathological processes such as inflammation and neoplasms (Janssens et al.,
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OHC is a potent regulator of
2020-09-01
25-OHC is a potent regulator of LXR-mediated pathways, that impact on RTA-408 lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]. 25-OHC is able to stimul
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A structural explanation for how RBR RING
2020-09-01
A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon
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br Experimental br Acknowledgments The
2020-09-01
Experimental Acknowledgments The work was supported in part by the National Research and Development Plan (2017YFD0200506), the National Natural Science Foundation of China (21472062 and 31701820), 111 Project B17019, and excellent doctoral dissertation cultivation Grant from Central China Nor
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br Material and methods br Results br Discussion The results
2020-08-31
Material and methods Results Discussion The results show for the first time that DDRs may be involved in the pathogenic mechanisms of neurodegenerative diseases. We found that DDR1 and DDR2 levels are up-regulated in post-mortem AD and PD brains, suggesting that these receptors play a role
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br EBV Infection Epstein Barr virus
2020-08-31
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T
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For example nM MTX markedly stimulates the differentiation o
2020-08-31
For example, 200nM MTX markedly stimulates the differentiation of the monocytic U937 amitriptyline hydrochloride [39], but only 10nM MTX is sufficient for the inhibition of clonogenicity in the ALL and APL cell lines [22]. Furthermore, an even lower concentration of MTX (2nM) selectively induces the
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The acetylcholinesterasic activity of exposed animals
2020-08-31
The acetylcholinesterasic activity of exposed animals, after treatment with diverse concentrations of uranium and following distinct recovery periods, remained unaltered for all species. This finding suggests that uranium, in spite of being a water-soluble metal, does not exert any effect on the sel
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br Results br Discussion Analysis
2020-08-31
Results Discussion Analysis of EBI2 expression showed that EBI2 is highly expressed in central memory CD8+ T cells that is in line with previous data from human T cells in which these 1-Azakenpaullone express higher levels of EBI2 than naive or effector memory CD8+ T cells (Hannedouche et al.
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br Results br Discussion Our UbV library was
2020-08-31
Results Discussion Our UbV library was originally designed to develop inhibitors of deubiquitinases (Ernst et al., 2013). Recently, we showed that UbVs could exhibit multiple binding modes and mechanisms to modulate HECT E3 activity (Zhang et al., 2016)—one set occupied the HECT domain E2-bind
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br Materials and methods br Results br
2020-08-29
Materials and methods Results Discussion Prolyl 4-hydroxylases are oxygenases with key roles in a variety of biological processes including oxygen sensing, siRNA regulation and collagen folding (Gorres and Raines, 2010). Hydroxyproline is particularly abundant in collagenous proteins which
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IAA sensitive Cl channels were
2020-08-29
IAA-94-sensitive Cl channels were shown to mediate cardioprotection due to IPC (Diaz et al., 1999) and cyclosporine A (Diaz et al., 2013). CLIC-like channel activity was also observed in cardiac mitoplast (Misak et al., 2013) but the molecular identity of these intracellular Cl channels and their pr
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EP is the major receptor to mediate PGE
2020-08-29
EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by chlorpromazine hydrochloride in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [1
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br The synthesis of these antagonists relied heavily on Stil
2020-08-28
The synthesis of these antagonists relied heavily on Stille and Suzuki coupling reactions. The preparation of the required building blocks is presented in . Reduction of ethyl 6-bromo-2-pyridinecarboxylate with diisobutylaluminum hydride in tetrahydrofuran followed by treatment with triisopropylsi
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