• Predictions of enzyme topology for

  2020-08-03

  

  Predictions of enzyme topology for DGAT2 are more difficult since the DGAT2 polypeptide sequences are more diverse across species than those of DGAT1. The length and function of the hydrophilic N-terminus preceding the first hydrophobic segment varies with species – for example, segments in fungi ar

• As shown in a previous

  2020-07-31

  

  As shown in a previous report (Donatti and Leite-Panissi, 2011), microinjection of CRF into the BLA or CeA of the guinea pig increased the duration of TI episodes compared to control episodes (Fig. 2A–D). However, when the microinjection of CRF into the BLA or CeA was preceded by the injection of CP

• Among the ERR family members ERR was

  2020-07-31

  

  Among the ERR family members, ERRγ was specifically upregulated in cartilage from human OA patients and various mouse models of OA. Gain-of-function (adenovirus-mediated overexpression in joint tissues or Tg mice) and loss-of-function ( mice or shRNA-mediated knockdown) approaches clearly indicate

• Multiple sclerosis MS is a frequent chronic inflammatory dis

  2020-07-31

  

  Multiple sclerosis (MS) is a frequent chronic inflammatory disease of the CNS leading to neurologic disability and lifelong morbidity in young adults (Compston and Coles, 2002). Despite advances in MS research, its pathophysiology is still far from being well understood, so it remains an incurable d

• To understand more about how the

  2020-07-31

  

  To understand more about how the UbVs interact with USP15, structures of some of the UbV-USP15 complexes were solved. In one crystal structure, the DUSP-binding UbV forms a strand-swapped dimer whereby the first β strand of each monomer is flipped 180° to interact with its partner. The exchange crea

• Present study measured only baseline

  2020-07-31

  

  Present study measured only baseline (preirradiation) levels of PARP-1 and DNA-PK expression. Due to study design, changes in these proteins that might occur during radiotherapy cannot be described. However, previous in vitro study has shown that there is a radiation-induced increase in the activity

• The enzymes involved in lipid biosynthesis

  2020-07-31

  

  The enzymes involved in lipid biosynthesis pathways have attracted considerable interest as potential targets for disruption of aberrant lipid accumulation and its resulting impact on a range of disease states.8, 9 Triglyceride biosynthesis and the resulting lipid burden placed on tissues are largel

• Inopportunely normal aging brings about decreases in frontal

  2020-07-31

  

  Inopportunely, normal aging brings about decreases in frontal D1 receptor densities and a gradual decline in postsynaptic markers of dopamine in striatal, neocortical, and limbic areas of the G007-LK australia (Bäckman et al., 2006, de Keyser et al., 1990, Karrer et al., 2017, Suhara et al., 1991,

• PLX3397 synthesis br Experimental section br Acknowledgment

  2020-07-31

  

  Experimental section Acknowledgment We gratefully acknowledge the financial support from the Spanish MINECO SAF2015-65113-C2-1-R to A.E.B. This project is also co-funded by the European Regional Development Fund (FEDER). PMA thanks to ACIISI for a predoctoral grant. We also thank to Prof. Alej

• Understanding the nature of protein collagen interactions is

  2020-07-30

  

  Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7

• proton pump inhibitors list Introduction Collagen deposition

  2020-07-30

  

  Introduction Collagen deposition is a common feature found in cancerous tissues and fibrotic organs/lesions. It is now well accepted that collagen deposition is not just a consequence of disease, but that it can also trigger a vicious cycle. Both chemical and physical signals elicited from collagen

• Contrary to genetic aberrations epigenetic methylation marke

  2020-07-30

  

  Contrary to genetic aberrations epigenetic methylation markers with broad coverage of OvCa subtypes were detected in primary tumors [21]. Ibanez de Caceres et al. [22] identified hypermethylation of BRCA1, APC, p16, p14, DAPK or RASSF1A in 50 of 50 primary tumors. Moreover the methylation pattern wa

• Introduction br Chronic inflammation state

  2020-07-30

  

  Introduction Chronic Garcinol state and MPN: Results from epidemiology Phenomena of autoimmune myelofibrosis or PMF presenting autoimmune phenomena have been reported [24], [25], [26]. A large population-based study including 11039 MPN patients and 43550 matched controls showed that 2.6% MPN pa

• Alexidine dihydrochloride Based on published reports and our

  2020-07-30

  

  Based on published reports and our own findings, we propose to combine genetic inactivation with pharmacological inhibition in mechanistic studies because the selectivity of many commercially available inhibitors is often limited. Experiments with non-selective inhibitors easily lead to misleading c

• For in vitro expression analysis of CXCL

  2020-07-30

  

  For in vitro expression analysis of CXCL8 and CXCRs by stimulated leucocytes, peripheral blood leucocytes (PBLs) were isolated using Percoll density gradient centrifugation as described earlier . Cell suspensions were adjusted to 5×10/ml. Four milliliters of tissue culture medium were plated per wel

14896 records 812/994 page Previous Next First page 上5页 811812813814815 下5页 Last page