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HvPap a member of the cathepsin F like family was
2020-08-10
HvPap-1, a member of the cathepsin F-like family, was identified in germinating barley seeds (Sreenivasulu et al., 2008). This enzyme participates in the mobilization of stored proteins (mainly hordeins) during the last phase of grain germination, and its activity is modulated by a propeptide or/and
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br Methods br Results Our study focused on consecutive postu
2020-08-10
Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement
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The two SNPs rs rs presented above
2020-08-10
The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT. This activity is inversely related to the sensitivity of pain in a chronic pain syndrome; so the haplotype (GCGG) h
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br Acknowledgements This work was supported
2020-08-10
Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem
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Early studies from the mollusk Aplysia reported the presence
2020-08-10
Early studies from the mollusk, Aplysia, reported the presence of a unique class of cyclin dependent kinases receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis elegans (Put
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Gamboge is a dry resin obtained from
2020-08-10
Gamboge is a dry resin obtained from Garcinia hanburyi HOOK. f. (Guttiferae). It has a variety of bioactivities, including detoxifying, homeostasis maintaining, anti-inflammatory and parasiticidic effects. Available evidence suggests that gamboge bears anticancer characteristics with gambogenic LB-1
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ERR induces the expression of P c in MA
2020-08-10
ERRγ induces the expression of P450c17 in MA-10 cells and in mouse primary Leydig cells (Fig. 2). Deletion mutant analysis of putative ERRγ-binding sites in the P450c17 promoter suggested that only the proximal third site located between −269 bp and −136 bp within the P450c17 promoter is functional
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We next turned our attention to the position
2020-08-10
We next turned our attention to the 6-position of the indole (). It was found that the chlorine atom present in was extremely important. The des-chloro analogue showed nearly 30-fold less affinity for the EP receptor in the binding assay and was nearly 30-fold lower in activity in the functional a
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Accordingly we prepared three compounds and as shown
2020-08-10
Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available CID 2011756 with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired comp
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Our previous high throughput screening
2020-08-08
Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based Heparin assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21], [22], [23],
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We first found that PGE synergizes with IL
2020-08-08
We first found that PGE2 synergizes with IL-23 and enhances Il23r expression through EP2 and EP4, a finding consistent with findings in human TH17 cells. We then found that IL-23 stimulation induces PGE2 production in TH17 cells and that IL-23–induced Il23r expression was attenuated by treatment of
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This data highlights as a novel EP
2020-08-08
This data highlights as a novel EP receptor antagonist with excellent in vivo efficacy. Compounds were synthesized according to the literature procedures or as outlined in , , , , , , . Full experimental details and characterizing data for key compounds has been described. Compound was prepared
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DGK metabolizes DG which enhances
2020-08-07
DGK metabolizes DG, which enhances PKC activity [10,11]. DGKδ regulates the EGFR pathway for the epithelial cell differentiation of lungs and skin [27] and controls insulin receptor signaling for glucose uptake in skeletal muscle [20] by attenuating cnPKC activities. In this study, we found that the
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The above mention strategy can
2020-08-07
The above mention strategy can be easily applied to explore the chemico-biological space of several efficient reactions such as MCRs in structure base drug discovery (SBDD) efforts. Most of these reactions if not all, are quite efficient, LY3009120 australia and step economical, diversity oriented
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br Conclusion To our knowledge this study
2020-08-06
Conclusion To our knowledge, this study is the first to examine the effect of an E2 + Levo hormone combination treatment, as well as E2-only and Levo-only treatments, on cognitive function in a preclinical model of surgical menopause. Hormone therapy, which can contain only estrogens, only proges
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