• Metaphit As with most G protein

  2023-02-07

  

  As with most G protein-coupled receptors (GPCRs), sustained activation of APJ can cause desensitization and this has been reported to occur for APJ-mediated effects on cytoplasmic Ca2+ concentration, as well as for effects on activity of adenylyl cyclase, ERK and Akt (Ishida et al., 2004, Masri et a

• Hsp also called FK binding protein FKBP

  2023-02-07

  

  Hsp56 (also called FK506-binding protein 52, FKBP52) is one of the steroid receptor-associated immunophilins with tetratricopeptide repeat domains, which serve as binding sites for Hsp90 (Peattie et al., 1992). Hsp56 is elevated in breast cancer compared with normal breast tissue (Ward et al., 1999)

• br Diabetic retinopathy Diabetic retinopathy is a severe

  2023-02-07

  

  Diabetic retinopathy Diabetic retinopathy is a severe sight-threatening complication associated with diabetes mellitus. It is one of the most common causes of preventable blindness in the world. The risk of developing microvascular diabetic complications increases in diabetic patients with an inc

• br Experimental section br Acknowledgements This work was

  2023-02-07

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• Dual acting RAAS blockade and neprilysin inhibition has been

  2023-02-07

  

  Dual-acting RAAS blockade and neprilysin inhibition has been evaluated in several clinical HF trials. In PARADIGM-HF [6,7], LCZ696 was superior to enalapril in reducing mortality and HF hospitalizations in symptomatic patients with HF with reduced EF. Augmented benefits on maladaptive cardiac remode

• The molecular mechanisms that mediate the plasticity

  2023-02-07

  

  The molecular mechanisms that mediate the plasticity of the NMJ are not well understood. PGC-1α is a master regulator of the NMJ gene expression program 23, 24, and thus AMPK might indirectly regulate the NMJ via its broad influence on the coactivator. Cerveró et al.[6] recently provided more direct

• br Experimental methods br Acknowledgments

  2023-02-07

  

  Experimental methods Acknowledgments Introduction Long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses are thought to underlie experience-dependent learning and memory. These synaptic plasticity mechanisms are best characterized at hippocampal CA1 synapses, whe

• br Introduction The traditional Chinese medicine

  2023-02-07

  

  Introduction The traditional Chinese medicine (TCM), Ganoderma (G.) lucidum Karst is a well-known mushroom which has been used clinically in some Asian countries. It is termed “Lingzhi” in China, “Reishi” in Japan and “Yeongji” in Korea. It has long been used in TCM for the promotion of longevity

• Herein we employ an adapted targeted quantitative proteomic

  2023-02-06

  

  Herein we employ an adapted targeted quantitative proteomic isotope dilution method, developed in our laboratory [[18], [19], [20], [21]], to quantify membrane transporters in fresh lung from five donors, in four immortalized human lung cell lines and in three control cell lines. We quantify twelve

• br A Rs which were

  2023-02-06

  

  A3Rs, which were cloned and then pharmacologically identified in the early 1990s, are expressed in multiple organs and peripheral tissues including mpep involved in inflammatory responses (Gessi et al., 2008, Borea et al., 2014). While low levels are expressed in the CNS, A3R agonists produce fun

• br Trauma and ACEs screening the

  2023-02-06

  

  Trauma and ACEs screening: the past, present, and future Traditionally, allopathy’s biomedical model has utilized an etic perspective; the outsiders’ view of the problem. Development of diagnostic screening tools requires an etic approach, which relies heavily on a completely objective perspectiv

• The synthetic route for the aminobenzoxazole scaffold with

  2023-02-06

  

  The synthetic route for the aminobenzoxazole scaffold with a solvent accessible moiety is described in . Nitration of methoxyphenol and subsequent hydrogenation of the resulting nitro Otilonium Bromide mg afforded compound . Aminobenzoxazole was formed by the reaction of compound with BrCN in EtO

• br Conclusion This is the first

  2023-02-06

  

  Conclusion This is the first report to show that treatment of lung cancer cell lines, A549 and H1299, with ovatodiolid stimulates intracellular reactive oxygen species generation and induces DNA damage. Subsequently activates ATM/ATR and CHK1/2 signaling pathway, inhibits CDC25C and p21WAF1/CIP1,

• Dopaminergic neurons are vulnerable to oxidative products an

  2023-02-06

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial receptor tyrosine kinase are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell

• YM 58483 br Nanoparticle Conjugated Topoisomerase Inhibitors

  2023-02-06

  

  Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5

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